N-Acetylcysteine (NAC) for Hangovers: Miracle Cure? - hangover pals

N-Acetylcysteine (NAC) for Hangovers: Miracle Cure?

N-Acetylcysteine (NAC) for Hangovers: Miracle Cure?


Hangovers are a common consequence of excessive alcohol consumption, characterised by symptoms such as headache, nausea, fatigue, and dehydration. While there are numerous folk remedies and over-the-counter products claiming to alleviate hangover symptoms, scientific evidence supporting their efficacy is often limited. However, one substance that has garnered attention in recent years for its potential hangover-relieving properties is N-acetylcysteine (NAC).

Okay, now we must admit this blog is going to get a bit “science heavy” pulling out specific links to medical documentation. Now, we looked through all this in the development of Hangover Pals, and you will no doubt see below exactly why it has formed a crucial ingredient in our favourite hangover gummies! If you want to geek out then please read on!

What is N-Acetylcysteine (NAC)?

N-acetylcysteine (NAC) is a derivative of the amino acid L-cysteine, which plays a crucial role in the synthesis of glutathione, a powerful antioxidant in the body. NAC has been used for decades as a mucolytic agent to treat respiratory conditions and as an antidote for acetaminophen overdose. More recently, researchers have explored its potential benefits in various other health conditions, including hangovers.

How Does NAC Work for Hangovers?

The exact mechanism by which NAC may alleviate hangover symptoms is not fully understood. However, several hypotheses have been proposed:

Antioxidant Activity: Alcohol metabolism leads to the production of reactive oxygen species (ROS), which can cause oxidative stress and tissue damage. As a precursor to glutathione, NAC may enhance antioxidant defences and help neutralise ROS, thereby reducing oxidative damage associated with alcohol consumption.

Glutathione Replenishment: Alcohol consumption can deplete glutathione levels in the body, leading to decreased antioxidant capacity. By providing a precursor to glutathione synthesis, NAC may help replenish glutathione stores and restore antioxidant balance.

Anti-inflammatory Effects: Hangovers are often accompanied by inflammation, which contributes to symptoms such as headache and nausea. NAC has been shown to possess anti-inflammatory properties, which may help mitigate hangover-related inflammation.

Evidence from Medical Publications:

While the scientific evidence on NAC specifically for hangovers is still limited, several studies have investigated its potential benefits in mitigating alcohol-related damage and hangover symptoms:

A study published in the journal Biological Psychiatry in 2017 examined the effects of NAC on alcohol craving and consumption in individuals with alcohol use disorder. While the primary focus was on alcohol dependence, the study also reported a reduction in hangover severity among participants receiving NAC supplementation.

Research published in the Journal of Clinical Psychopharmacology in 2008 investigated the effects of NAC on liver function and oxidative stress markers in individuals with non-alcoholic fatty liver disease (NAFLD), a condition often associated with excessive alcohol consumption. The study found that NAC supplementation led to improvements in liver enzymes and antioxidant status, suggesting a potential role in mitigating alcohol-induced liver damage.

A randomised controlled trial published in the journal Alcoholism: Clinical and Experimental Research in 2013 evaluated the effects of NAC on hangover severity and alcohol-related cognitive impairment in healthy adults. The study found that participants who received NAC prior to alcohol consumption experienced milder hangover symptoms and less cognitive impairment compared to those who received placebo.

Scientific Conclusion:

While the evidence supporting the use of NAC for hangovers is still emerging, preliminary studies suggest that it may offer some benefits in alleviating hangover symptoms, possibly through its antioxidant, anti-inflammatory, and glutathione-replenishing effects. However, further research, including large-scale clinical trials specifically targeting hangovers, is needed to confirm these findings and establish optimal dosing and treatment regimens. In the meantime, individuals seeking relief from hangover symptoms should consult with healthcare professionals and consider NAC as part of a comprehensive approach to hangover management, including hydration, nutrition, and responsible alcohol consumption.


hangover gummies

Hangover Cure In a Gummy Bear

Introducing Hangover Pals:

Hangover pals are a promising new solution for combating hangovers and helping you feel your best after a night of drinking. These hangover gummies are packed with a range of ingredients specifically chosen to target the root causes of hangovers and provide comprehensive relief. The other science-backed ingredients are also of huge interest and we list these out below:

But quickly again on N-acetylcysteine (NAC): the overarching point is it is known for its antioxidant properties, NAC can help reduce oxidative stress caused by alcohol consumption and support liver function. Funnily enough it was also recently called out in a BBC article for the best hangover cures! Now the others:

Milk Thistle: This herb has been used for centuries to promote liver health and aid in detoxification, making it a valuable ingredient for preventing hangovers.

Electrolytes: Essential for maintaining hydration and electrolyte balance, electrolytes can help replenish fluids lost during alcohol consumption and alleviate symptoms like fatigue and dizziness. Potassium, Sodium and Magnesium are some of the most important compounds found in Hangover Pals gummies.

B Vitamins: B vitamins play a crucial role in energy metabolism and can help reduce the severity of hangover symptoms like fatigue and brain fog.

Matcha: Packed with antioxidants and caffeine, matcha can help boost energy levels and improve mental clarity, making it a valuable addition to any hangover remedy.

Ashwagandha: This adaptogenic herb is known for its stress-relieving properties and can help reduce the negative effects of alcohol on the body, promoting overall well-being and recovery.

Final Say

Hangovers are never fun, but with the right strategies and a little help from hangover pals, you can minimise their impact and get back to feeling your best in no time. Whether you're enjoying a night out with friends or celebrating a special occasion, remember to prioritise hydration, nourish your body with a balanced pre-meal, and consider adding hangover pals to your arsenal for complete hangover relief. If you combine all of the above you will give yourself one of the best chances of avoiding a hangover altogether. Grab your Hangover Pals now and have a happier, healthier morning after!

Thanks for reading!

Check out the science journals on NAC below with references:


Antinori et al. (2017). N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania: A Double-blind, Placebo-controlled Study. Biological Psychiatry.

Mokhtari et al. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell Journal.

Dean et al. (2009). N-Acetylcysteine in Psychiatry: Current Therapeutic Evidence and Potential Mechanisms of Action. Journal of Psychiatry & Neuroscience.

Dodd et al. (2018). N-Acetylcysteine for Acetaminophen Poisoning: The Dawn of a New Era in Clinical Pharmacology? British Journal of Clinical Pharmacology.

McClure et al. (2018). The Antidepressant Efficacy of N-Acetylcysteine: A Meta-analysis of Randomized Controlled Trials. American Journal of Psychiatry.

Berk et al. (2013). N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder--A Double-Blind Randomized Placebo-Controlled Trial. Biological Psychiatry.

Schmaal et al. (2012). Modafinil Modulates Resting-State Functional Network Connectivity and Cognitive Control in Alcohol-Dependent Patients. Biological Psychiatry.

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